两个北欧国家之间婴儿先天性密码症患病率的差异
K A Boisen1, M Kaleva, K M Main
1University Department of Growth and Reproduction, Rigshospitalet DK-2100 Copenhagen, Denmark.
Lancet (London, England)
|April 20, 2004
概括
先天性密码症,或未下降的丸,在丹麦男孩中比芬兰男孩更为常见. 这一发现可能解释了丹麦生殖健康问题的更高率,可能是由于环境因素.
科学领域:
- 生殖健康 生殖健康
- 儿科内分泌学 儿科内分泌学
- 环境流行病学环境流行病学
背景情况:
- 丹麦和芬兰在精液质量和丸癌率方面存在差异.
- 先天性密码症 (未下降的丸) 是这些生殖健康问题的共同风险因素.
研究的目的:
- 开展一项关于丹麦和芬兰先天性密码虫病的流行情况的联合前性研究.
- 调查密码虫病率的地理差异及其与生殖健康结果的潜在联系.
主要方法:
- 预计将在产前招募1068名丹麦和1494名芬兰男孩.
- 在出生和3个月大时对丸位置的标准化评估.
- 包括所有先天性形症亚型,不包括可收缩的丸.
主要成果:
- 在丹麦,密码症的出生率为9.0%,在芬兰为2.4%.
- 在3个月后,丹麦的患病率为1.9%,芬兰为1.0%.
- 在调整了混因素后,地理差异仍然存在,丹麦的几率明显更高.
结论:
- 丹麦先天性密码症的更高和越来越多的患病率支持了生殖健康问题的模式.
- 虽然遗传学可能起作用,但内分泌干扰物和生活方式等环境因素可能是观察到的差异的原因.
- 这些发现突出了对男性生殖健康结果的潜在环境影响.
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