菲律宾的方向通过线性二元论揭示. 对于一个行动模式的含义
Sílvia C D N Lopes1, Erik Goormaghtigh, Benedito J Costa Cabral
1Centro de Química-Física Molecular, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.
Journal of the American Chemical Society
|April 29, 2004
概括
菲律宾在脂质膜中的抗生素导向取决于胆固醇的存在和脂质阶段. 在存在胆固醇或液晶相的情况下,菲律宾插入垂直于膜表面,解决了关于其组织的争论.
科学领域:
- 膜生物物理学 膜生物物理学
- 抗微生物药物药物相互作用
- 脂质 - 胆固醇相互作用
背景情况:
- 聚烯抗生素菲律宾在含胆固醇的膜中的组织受到争论.
- 两个模型提出了菲律宾与膜平面相对平行或垂直的方向.
研究的目的:
- 为了研究菲律宾在带有和没有胆固醇的模型膜中的方向.
- 解决关于菲律宾膜组织的争议.
主要方法:
- 使用紫外线对线性二极化,ATR-FTIR和光异性衰变.
- 在1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) 和1,2-palmitoyl-sn-glycero-3-phosphocholine (DPPC) 模型膜中研究了filipin,含有和没有胆固醇.
主要成果:
- 菲律宾的方向是凝阶段 (DPPC) 膜中的胆固醇依赖.
- 在33%胆固醇的DPPC中,菲律宾垂直方向,与毛孔形成模型一致.
- 菲律宾显示DPPC中没有胆固醇的随机组织.
- 在液晶相 (POPC) 膜中,菲律宾的方向是垂直的,不论胆固醇是否存在.
结论:
- 菲律宾人的活动和组织受到胆固醇存在和脂质阶段的影响.
- 这些发现协调了关于菲律宾-胆固醇相互作用的相互矛盾的文献数据.
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