腹腔壁中的室内虚拟电极:对心上心膜极化的影响
Oleg F Sharifov1, Vladimir G Fast
1Department of Biomedical Engineering, University of Alabama at Birmingham, AL 35294, USA.
Circulation
|May 1, 2004
概括
通过光学记录,在心脏表面检测到室内虚拟电极 (IVE). 这些发现表明,可能由原形成的IVEs会影响除.
科学领域:
- 心血管生理学心血管生理学
- 生物物理学的生物物理.
- 医疗成像医学成像
背景情况:
- 内部虚拟电极 (IVE) 假设对除至关重要.
- 它们在完整的心肌中的存在以前没有被证明.
- 这项研究旨在在完整的心脏组织中提供IVEs的光学证据.
研究的目的:
- 在完整的心肌中光学检测室内虚拟电极 (IVEs).
- 调查IVEs在冲击诱导的跨膜潜能变化中的作用.
- 为了将光学发现与潜在IVE基质的组织学证据相关联.
主要方法:
- 用表面染色 (SS) 和全球染色 (GS) 方法染色分离的猪心室.
- 冲击诱导的跨膜电位变化 (DeltaV(m)) 从心表表面光学记录.
- 在不同冲击强度和方向下分析光学信号.
主要成果:
- 光学记录显示了SS和GS方法之间的DeltaV (m) 显著差异,特别是随着冲击强度的增加.
- 阴极GS-DeltaV(m) 呈现出多相和负的潜力,与单相和正的SS-DeltaV(m) 相反.
- 组织学检查在心脏下部发现了原,与IVE的基质一致.
结论:
- 内腔虚拟电极 (IVE) 可以通过对心表表面电位的光学测量来检测.
- 观测到的光学信号支持心下静脉动器对除的贡献.
- 微观的电阻不连续性,可能由原形成,可能构成IVEs的基质.
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