葡萄糖皮质激素治疗可以预防由实验性冠状动脉微栓塞引起的渐进性心肌功能障碍
Andreas Skyschally1, Michael Haude, Hilmar Dörge
1Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Essen, Federal Republic of Germany.
Circulation
|May 1, 2004
概括
甲基普雷迪尼索隆可以防止在微栓塞后的渐进性心脏功能障碍. 这种抗炎治疗,即使在事件发生后进行,也能减轻急性冠状动脉综合征的长期损伤.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 炎症研究 炎症研究
背景情况:
- 微栓塞在急性冠状动脉综合征和干预中越来越被认可.
- 实验性微栓塞会导致立即的功能障碍,随后几个小时的逐渐收缩功能障碍.
- 这种延迟功能障碍与炎症有关,而不是血液流量减少.
研究的目的:
- 为了研究抗炎性葡萄皮质激素治疗对微栓塞后逐渐收缩功能障碍的影响.
主要方法:
- 在犬冠状动脉中使用微球诱导的微栓塞.
- 狗在微栓塞前或之后接受安慰剂或甲基prednisolone (IV).
- 在8小时和1周内评估心脏功能和白细胞透.
主要成果:
- 安慰剂组在微栓塞后8小时内,缩壁的厚度显著下降.
- 甲基普雷迪尼索隆的使用可以防止心肌功能障碍的进展.
- 只有在治疗前给予甲基前尼索隆时,白细胞透率才会降低.
结论:
- 甲基普雷尼索隆有效地防止微栓塞后逐渐收缩功能障碍.
- 即使在微栓塞事件后使用,也观察到治疗效果.
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