移植后大脑中的骨髓转分化:一项回顾性研究
Christopher R Cogle1, Anthony T Yachnis, Eric D Laywell
1Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL 32610, USA.
Lancet (London, England)
|May 4, 2004
概括
成人人体造血干细胞可以成为脑细胞,在没有融合的情况下进行长期修复. 这一发现支持它们作为再生神经生成疗法的来源的潜力.
科学领域:
- 神经科学是一个神经科学.
- 干细胞生物学 干细胞生物学
- 再生医学是一种再生医学.
背景情况:
- 研究成人造血干细胞的可塑性和末端器官修复能力.
- 检查骨髓修复大脑组织的潜力,挑战现有的观念.
- 专注于临床相关的骨髓衍生的修复性神经发生的证据.
研究的目的:
- 为了确定人类造血干细胞是否可以在大脑中实现长期的多系神经移植.
- 调查这种植入是否通过转分化或细胞融合发生.
主要方法:
- 来自三个性别不匹配的骨髓移植患者的尸检大脑样本的分析.
- 使用免疫组织化学,光现场杂交和组织分析.
- 寻找多血统,来自捐赠者的神经发生和细胞融合的证据.
主要成果:
- 在移植后的6年内,在海马体中发现含有Y染色体的细胞 (来源于捐赠者).
- 跨性别神经元占所有神经元的1%,没有融合的证据 (单个X染色体).
- 跨性别星体细胞和微质细胞占质细胞的1-2%.
结论:
- 产后人类神经构造发生,血液构造细胞转化为神经系.
- 人体造血细胞可以长期形成神经元,星体细胞和微质细胞,而无需融合.
- 可移植的造血细胞代表了再生神经形成的潜在治疗来源.
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