侵袭性细菌的先天免疫识别在阿波利波蛋白E缺乏的小鼠中加速动脉样硬化
Frank C Gibson1, Charlie Hong, Hsin-Hua Chou
1Department of Medicine, Section of Infectious Diseases, Boston University Medical Center, Boston, Mass, USA.
Circulation
|May 5, 2004
概括
传染病,如牙周病,可以增加心血管疾病的风险. 侵入性 Porphyromonas gingivalis 加快动脉样硬化,但受损菌株没有,这表明侵入性是关键.
科学领域:
- 心血管研究研究心血管研究
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 传染病越来越多地被认为是心血管疾病 (CVD) 的危险因素.
- 流行病学研究表明,牙周病和心血管疾病之间存在联系.
- 牙周病是一种慢性炎症状况,影响支牙的组织.
研究的目的:
- 调查牙周病和动脉样硬化之间的直接因果关系.
- 确定牙周病原体 Porphyromonas gingivalis 在加速动脉样硬化的作用.
主要方法:
- ApoE-/-小鼠被口服挑战野生类型的 Porphyromonas gingivalis 或侵袭受损突变 (FimA-).
- 在血液和大动脉组织中检测细菌使用PCR进行.
- 评估了动脉样硬化斑块的发展和大动脉组织中的先天性免疫标记物 (TLR-2,TLR-4) 的表达.
- 评估了针对P. gingivalis的免疫对动脉样硬化的影响.
主要成果:
- 野生类型的P. gingivalis和FimA突变都在小鼠血液和大动脉组织中检测到.
- 被野生型P. gingivalis挑战的小鼠表现出动脉样硬化斑块增加和TLR-2和TLR-4表达升高.
- 被FimA突变挑战的小鼠没有发展牙周病,TLR上调或加速动脉样硬化.
- 预防牙周病的免疫接种也可以预防P. gingivalis加速动脉样硬化.
结论:
- 侵袭性 Porphyromonas gingivalis 直接加速动脉样硬化.
- 牙周杆菌的侵入性对于其在促进动脉样硬化中的作用至关重要.
- 控制牙周病可能会减轻由P. gingivalis加速动脉样硬化的风险.
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