氧八甲基酸盐的氧化碎片化产生生物活性的-基甲
Mingjiang Sun1, Robert G Salomon
1Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44107-7078, USA.
Journal of the American Chemical Society
|May 6, 2004
概括
在体内丰富的氧基,在氧化物存在时可以分裂形成细胞毒性-基基. 这一途径对于理解脂质氧化和疾病发展至关重要.
科学领域:
- 生物化学 生物化学
- 利皮多米克 (Lipidomics) 是一种消化剂.
- 氧化压力是一种氧化压力.
背景情况:
- 多不和脂肪酸 (PUFA) 的碎片化产生细胞毒性化物.
- 马-基基酸胆 (PCs) 是生物活跃的,并与疾病有关.
研究的目的:
- 为了研究氧基的氧化碎片化,一种常见的体内脂质氧化产物.
- 确定氧基作为生成玛-氧基的中间体的作用.
主要方法:
- 采用了一种生理模拟模型研究,使用了小的单状囊泡.
- 采用了由髓氧化酶促进的自由基诱导的碎片化.
- 分析了氧和氧烯的碎片化产物.
主要成果:
- 氧基在氧化物存在时分裂为-基基.
- 观察到9-基-12-氧多德克-10-酸 (HODA) 的形成HODA-PC.
- 氧基在体内是可信的中间体,用于氧化截断的脂质生产.
结论:
- 氧基有助于体内产生细胞毒性玛-氧基.
- 对PUFA的氧化碎片化而言,二氧化中间体的形成不是必不可少的.
相关概念视频
Habitat Fragmentation
21.4K
Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
21.4K
Biological Effects of Radiation
18.0K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.0K
Oxidation Numbers
42.9K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
42.9K
Pyruvate Oxidation
169.0K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.0K
What is Conservation Biology?
24.4K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.4K
Oxidation-Reduction Reactions
75.8K
Oxidation–Reduction Reactions
75.8K


