自然主义的经验改变了被关在子里的成年动物大脑皮层中的感觉地图
Daniel B Polley1, Eugen Kvasnák, Ron D Frostig
1Department of Neurobiology and Behavior, University of California, Irvine, California 92697-4550, USA. dpolley@phy.ucsf.edu
Nature
|May 7, 2004
概括
将成年大鼠从实验室子转移到自然息地显著重塑了它们的大脑.
科学领域:
- 神经科学是一个神经科学.
- 感官处理 感官处理
- 神经可塑性 神经可塑性
背景情况:
- 成年人感官皮层组织主要在标准实验室环境中进行研究.
- 对自然环境如何影响已建立的皮质地图的有限理解.
研究的目的:
- 研究自然息地对大鼠体感皮层的功能和形态组织的影响.
- 为了确定自然行为是否完善皮质感官表现.
主要方法:
- 成年老鼠从实验室子转移到自然的息地.
- 重复的内在信号光学成像以可视化胡须表示.
- 急性多部位细胞外记录以评估神经元反应和受体场.
主要成果:
- 在自然息地4-6周后,皮层胡须的表现在自然息地4-6周后收缩了46%.
- 上层皮质层 (II/III) 显示神经元反应被抑制,受体场较小.
- 第四层表现出较小的形态可塑性,明显小于功能变化.
结论:
- 自然主义的环境促进先天的行为,诱导大规模的功能精细化皮质感官图.
- 环境丰富显著影响成年大脑的可塑性和感官地图组织.
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