放松素是一种独立的风险因素,可预测末期病的男性患者的死亡
Berthold Hocher1, Reinhard Ziebig, Rolfdieter Krause
1Humboldt University of Berlin, University Hospital Charité, Center for Cardiovascular Research, Department of Nephrology, Charité, Berlin, Germany. berthold.hocher@charite.de
Circulation
|May 12, 2004
概括
高水平的放松素预测,在接受血液透析的末期病 (ESKD) 的男性患者中死亡. 这一发现强调了放松素作为该人口中死亡率的重要风险因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
背景情况:
- 末期病 (ESKD) 患者的预期寿命减少,主要是由于心血管疾病.
- 放松素已被确定为心血管疾病发展的潜在因素.
研究的目的:
- 研究放松素对ESKD患者死亡率的影响.
- 确定放松素是否是接受血液透析的ESKD患者死亡的独立风险因素.
主要方法:
- 在长期进行血液透析的245名患者中,对1140天的死亡率进行了随访.
- 在进入研究时,测量了relaxin和其他生物标志物的血清度.
- 使用Kaplan-Meier和Cox回归方法进行了生存分析.
主要成果:
- 血清中放松素度升高预测男性患者的全因和心血管死亡.
- 患有高放松素的男性全因死亡的相对风险为2.63 (P=0.005).
- 在女性患者中,放松素水平和死亡之间没有发现显著的关联.
结论:
- 放松素是预测慢性血液透析ESKD男性患者死亡的独立风险因素.
- 这些发现表明,放松素在ESKD死亡率中的性别特异性作用.
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