通过来自收费类受体的信号来调节细胞成熟
J Magarian Blander1, Ruslan Medzhitov
1Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
概括
收费类受体 (TLR) 信号调节细菌的细胞形成,影响细胞内化和细胞成熟. 这条通路对于宿主防御至关重要,但对于清除亡细胞至关重要.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- fagocytosis 对于宿主防御和细胞碎片清除在元动物中至关重要.
- 微生物和亡细胞共享一个通往溶酶体的通路,以便降解.
研究的目的:
- 研究托尔类受体 (TLR) 信号在调节细胞形成中的作用.
- 确定TLR信号如何影响微生物和亡细胞的内化和细胞成熟.
主要方法:
- 研究了高层甲基动物的细胞化.
- 研究了细菌和亡细胞对TLR信号通路激活的影响.
- 分析了包括内化和细胞成熟在内的细胞化步骤.
- 观察到法体成熟的构成性和诱导性模式.
主要成果:
- 细菌的TLR信号激活,而不是apoptotic细胞,调节了多个细胞化步骤.
- 由于没有TLR信号传递,细菌的细胞化显著受损.
- 鉴定出了两个不同的细胞成熟模式 (构成性和诱导性).
- 这些成熟模式的激活取决于货物能够触发TLR信号的能力.
结论:
- TLR信号传递是细菌细胞酶的关键调节者,影响吸收和细胞内处理.
- 细胞成熟路径根据货物的性质及其激活TLR的能力而受到不同的调节.
- 这些发现突显出一种特定的机制,通过这种机制,免疫系统在细胞形成过程中区分病原体和自衍生的亡物质.
相关概念视频
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Diversity in Cell Signaling Responses
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
Graded and Abrupt Responses
Some signaling systems generate...
Graded and Abrupt Responses
Some signaling systems generate...
Cell Signaling Feedback Loops
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
Feedback Regulation of Calcium Concentration
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Overview of Cell Signaling
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
Signal Transduction: Overview
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Typically, signal transduction involves three...


