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相关概念视频

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...

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相关实验视频

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A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography
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血清脂聚糖结合蛋白预测严重的细菌感染在肝硬化患者与.

Agustín Albillos1, Antonio de-la-Hera, Melchor Alvarez-Mon

  • 1Laboratorio de Enfermedades del Sistema Inmune y Oncología, Unidad I+D Asociada al CSIC, Departamento de Medicina, Universidad de Alcalá, Carretera Madrid-Barcelona, KM 33.600, 28871 Alcalá de Henares, Madrid, Spain. aalbillosm@meditex.es

Lancet (London, England)
|May 18, 2004
PubMed
概括

血清脂聚糖结合蛋白 (LBP) 的升高表明,在患有炎的肝硬化患者中,严重细菌感染的风险更高. 监测LBP可能有助于识别需要抗生素预防的个人.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 传染性疾病 传染性疾病
  • 临床微生物学 临床微生物学

背景情况:

  • 肝硬化患者的结与细菌感染的风险增加有关.
  • 血清脂聚糖结合蛋白 (LBP) 的升高表明肠道屏障功能障碍和细菌转移.
  • 识别患有严重细菌感染 (SBI) 高风险的患者对于及时干预至关重要.

研究的目的:

  • 为了前性地调查患有肝硬化和瘤的患者SBI第一个发作的风险因素.
  • 确定血清LBP水平与SBI发生率之间的关联.
  • 评估血清LBP作为SBI预测标记物的潜力. 在这个人群中.

主要方法:

  • 在84名肝硬化患者的前性队列研究中.
  • 平均随访时间为46周.
  • 多变量分析以确定SBI的独立风险因素,包括血清LBP水平.

主要成果:

  • 血清LBP升高的患者 (32.4%) 的SBI累积概率明显高于正常水平 (8.0%) (p=0.004) 的患者 (32.4%).
  • 血清LBP增加是SBI的唯一独立预测因子 (相对风险4.49,95%CI1.42-14.1).
  • 在有或没有明显感染的患者之间,没有观察到感染率的显著差异.

结论:

  • 血清LBP是严重的细菌感染的重要独立风险因素,在患有炎的肝硬化患者.
  • 监测血清LBP水平可以帮助识别高风险患者.
  • 针对性抗生素预防对于肝硬化患者,风和升高的LBP可能是有益的.