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相关概念视频

Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

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相关实验视频

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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

Published on: July 2, 2013

在患有1至3个大脑转移的患者中,全脑辐射疗法与或没有立体射线手术促进:RTOG 9508随机试验的III期结果.

David W Andrews1, Charles B Scott, Paul W Sperduto

  • 1Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. david.andrews@jefferson.edu

Lancet (London, England)
|May 26, 2004
PubMed
概括

立体射线手术提升改善了单个脑转移患者的生存和功能状态. 这种治疗建议用于单一转移,并考虑用于多重转移.

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科学领域:

  • 辐射瘤学 辐射瘤学
  • 神经外科 神经外科
  • 医学瘤学 医学瘤学

背景情况:

  • 大脑转移会影响高达40%的癌症患者.
  • 在一项随机试验中评估立体射线手术 (SRS) 的治疗益处.

研究的目的:

  • 为了评估SRS增强后整个大脑辐射疗法 (WBRT) 对大脑转移的疗效.

主要方法:

  • 随机试验比较WBRT与WBRT加SRS提升.
  • 根据转移的数量和脑外疾病状态分层的患者.
  • 主要终点:生存;次要终点:瘤反应,局部控制,复发,死亡原因,表现状况.

主要成果:

  • WBRT加上SRS显示,单次大脑转移患者的生存优势 (6.5与4.9个月,p=0.0393).
  • 在SRS组6个月后改善了卡诺夫斯基绩效状态 (KPS) (43%对27%,p=0.03).
  • 多变量分析表明,RPA 1类和有利的组织学改善了生存率.

结论:

  • WBRT加上SRS提升可提高单个不可切除的大脑转移的功能自主性 (KPS) 和存活率.
  • 在单个转移中,SRS增强应该是标准的,在2-3个转移中应考虑.