在非常小的儿童中治疗严重肺炎的:双盲安慰剂对照试验
W Abdullah Brooks1, M Yunus, Mathuram Santosham
1Centre for Health and Population Research, International Centre for Diarrhoeal Disease Research, Bangladesh, GPO Box 128 Mohakhali, Dhaka 1000, Bangladesh. abrooks@icddrb.org
Lancet (London, England)
|May 26, 2004
概括
补充剂显著减少了儿童严重肺炎的持续时间. 这种干预措施还缩短了住院时间,为儿童肺炎提供了经济有效的治疗方法.
科学领域:
- 儿童传染病 儿童传染病
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 全球范围内,肺炎是儿童疾病和死亡的主要原因.
- 在严重的肺炎中,早期症状的缓解改善了患者的治疗结果.
- 作为急性相反应剂的作用表明了潜在的治疗益处.
研究的目的:
- 调查补充剂是否能缩短儿童严重肺炎的持续时间.
- 为了确定对儿科肺炎患者住院时间的影响.
- 评估作为严重肺炎的辅助疗法.
主要方法:
- 这是一项双盲,安慰剂控制的试验,涉及270名2-23个月龄的儿童.
- 参与者每天接受20毫克元素或安慰剂,同时接受标准抗菌药物治疗.
- 测量结果包括严重肺炎症状消失的时间和医院出院的时间.
主要成果:
- 补充剂显著减少了严重肺炎的持续时间 (RH=0.70).
- 治疗还缩短了整体住院时间 (RH=0.75),平均减少了一天.
- 当有喘息的儿童被排除在分析之外时,影响更为明显.
结论:
- 每天20毫克的可以加速重症肺炎儿童的康复.
- 可以通过减少多种抗生素的暴露来降低抗生素耐药性.
- 这种干预可以减少资源有限的环境中的并发症和死亡率.
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