迪尔提亚对人类心房节点性质的速度依赖性影响
Circulation
|September 1, 1992
概括
迪尔蒂亚泽姆 (Diltiazem) 在他们的身上.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 心率显著影响抗心律失常药物的疗效.
- 关于通道阻断剂对人类心房 (AV) 节点性质的频率依赖作用的数据有限.
研究的目的:
- 为了研究心率对diltiazem在人类的电生理学影响的影响.
- 了解德尔提亚对AV节点功能的频率依赖作用.
主要方法:
- 在25名患者中进行电生理学研究.
- 在各种心房速率下评估鼻节点,心房和AV节点功能.
- 进行了三次静脉注射的迪尔提亚泽姆,以达到稳定的血度.
主要成果:
- 迪尔提亚的剂量取决于增加了温克巴赫周期的长度.
- 影响主要是AV节点参数,对鼻节点或心房功能的影响最小.
- 在心率快的情况下,迪尔提阿泽姆对心室膜有效耐火期 (AVERP) 的影响显著增加.
结论:
- 迪尔提亚对人类AV结节功能的抑郁作用高度依赖于速率.
- 对AV节点折射率的速率依赖作用可能有助于diltiazem在 supraventricular arrhythmias中的疗效.
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