氧气吸入对患有外围动脉封闭性疾病的患者皮肤微循环的影响
O Bongard1, H Bounameaux, B Fagrell
1Department of Medicine, University Hospital of Geneva, Switzerland.
Circulation
|September 1, 1992
概括
补充氧气可以在周围动脉封闭性疾病 (PAOD) 患者中缩小或增加脚皮肤微循环. 影响取决于疾病的严重程度,影响血液流动,并可能改善血液循环不良.
科学领域:
- 心血管医学 心血管医学
- 身体生理学 身体生理学
- 医学研究 医学研究
背景情况:
- 氧气疗法用于缺血,但其对微循环的影响仍在争论中.
- 周围动脉封闭性疾病 (PAOD) 影响到四肢的血液流动.
- 研究氧气对PAOD皮肤微循环的影响至关重要.
研究的目的:
- 为了检查40%氧气吸入对脚皮肤微循环的影响.
- 为了区分正常人与PAOD患者的反应.
- 为了将微循环变化与皮肤间的氧气张力 (tc PO2) 相对应.
主要方法:
- 在脚上测量了通过皮肤的氧气张力 (tc PO2).
- 评估了使用激光多普勒流量计 (LDF) 和动态毛细管显微镜 (CBV) 的指甲折叠微循环.
- 在氧气吸入过程中,对11名PAOD患者和8名健康对照者的反应进行了比较.
主要成果:
- 氧气吸入减少了正常受试者和PAOD患者的微循环,增加了tc PO2.
- 在PAOD患者中,微循环显著增加,但没有显著的tc PO2升高.
- 在PAOD患者中,氧气改善了受损流动.
结论:
- 40%的氧气会在正常人和中度PAOD中引起血管收缩.
- 严重的PAOD患者经历了氧气增加的皮肤微循环.
- 氧疗对PAOD微循环的影响取决于疾病的严重程度.
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