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相关概念视频

Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Antigen Processing Pathways01:31

Antigen Processing Pathways

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MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
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相关实验视频

Updated: Apr 30, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

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通过MHCII路径处理和呈现多糖.

Brian A Cobb1, Qun Wang, Arthur O Tzianabos

  • 1Channing Laboratory, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA.

Cell
|May 28, 2004
PubMed
概括

紫多糖 (ZPSs) 通过MHCII类通路进行处理和呈现,从而激活CD4 ((+) T细胞. 这一发现挑战了碳水化合物免疫反应和T细胞激活的传统观点.

科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 微生物学 微生物学

背景情况:

  • 适应性免疫依赖于抗原呈现细胞 (APC) 和T细胞.
  • 甲类MHC向CD8(+) T细胞呈现细胞内;乙类MHC向CD4(+) T细胞呈现细胞外.
  • 人们认为碳水化合物可以引起独立于T细胞的免疫反应.

研究的目的:

  • 为了研究zwitterionic多糖化合物 (ZPSs) 激活CD4 ((+)) T细胞的机制.
  • 探索MHCII类途径在ZPS介导的T细胞激活中的作用.

主要方法:

  • 通过氧化介导机制对ZPS加工的分析.
  • 通过MHCII类内细胞通路对T细胞呈现ZPS的研究.
  • 在APC中检查碳水化合物与MHCII类结合的情况.

主要成果:

  • 酸多糖 (ZPSs) 被加工成低分子量碳水化合物.
  • 这些加工的碳水化合物通过MHCII类内细胞通路向T细胞呈现.
  • 来自ZPSs的碳水化合物与APC中的MHCII类分子结合.

结论:

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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis

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Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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  • ZPSs可以激活CD4 (((+) T细胞,表现出T细胞依赖的免疫反应.
  • 这种激活通过MHCII类途径发生,这是碳水化合物呈现的新机制.
  • 这些发现表明,理解碳水化合物如何通过T细胞激活来调节免疫反应的范式转变.