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相关概念视频

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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
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在多发性硬化症中,父母的起源效应:在半兄弟姐妹的观察.

G C Ebers1, A D Sadovnick, D A Dyment

  • 1The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. george.ebers@clinical-neurology.oxford.ac.uk

Lancet (London, England)
|June 3, 2004
PubMed
概括

多发性硬化症 (MS) 的易感性可能受到母亲因素的影响. 这项研究发现,与父异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母异母.

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科学领域:

  • 遗传学 是一个遗传学.
  • 神经学 神经学
  • 流行病学 流行病学

背景情况:

  • 多发性硬化症 (MS) 是一种复杂的神经系统疾病,与一般人群相比,后代的发病率明显高.
  • 鉴定MS的原始源效应是具有挑战性的,因为这种疾病的性质主要是零星的.

研究的目的:

  • 调查潜在的原始母体对多发性硬化症易感性的影响.
  • 为了比较受影响家庭中母亲和父亲半兄弟姐妹之间的复发风险.

主要方法:

  • 采用了比较性研究设计,分析了多发性硬化症指数病例的兄弟姐妹中复发风险.
  • 从加拿大多发性硬化症诊所收集了1567个半兄弟姐妹的索引病例的数据,记录了3436个半兄弟姐妹和2706个完全兄弟姐妹.
  • 根据年龄调整的复发风险被计算出来,并将完全兄弟姐妹,半兄弟姐妹,母亲的半兄弟姐妹和父亲的半兄弟姐妹进行了比较.

主要成果:

  • 多发性硬化症的年龄调整全兄弟姐妹风险为3.11%.
  • 半兄弟姐妹的整体风险明显低于1.89% (p=0.006),但高于纯多基因遗传的预期.
  • 母亲半兄弟姐妹的复发风险较高 (2.35%) 与父亲半兄弟姐妹 (1.31%) 相比,具有统计学上显著的差异 (p=0.048).

结论:

  • 这些发现表明,母亲的原始亲对多发性硬化症的易感性有很大的影响.
  • 这表明,从母亲传播的遗传或环境因素在MS发展中起着至关重要的作用.