Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Hormonal Regulation01:33

Hormonal Regulation

30.4K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
30.4K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

4.4K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
4.4K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.8K
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

7.8K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
7.8K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

765
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
765
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Rethinking the impact of dietary sodium and potassium on blood pressure to advance public health.

The American journal of clinical nutrition·2026
Same author

Rural Computed Tomography - a model for access to rapid stroke care in sparsely populated areas?

BMC health services research·2026
Same author

Normal abundance of immune cells in left ventricular myocardium from patients with heart failure and preserved ejection fraction.

European journal of heart failure·2026
Same author

Substrate utilization during short-term fasting in older men and women.

American journal of physiology. Endocrinology and metabolism·2026
Same author

Call to action: a need for community-driven minimum information standards for food composition data.

The American journal of clinical nutrition·2025
Same author

Effects of diltiazem and metoprolol on levels of high-sensitivity troponin I in patients with permanent atrial fibrillation: a randomized trial.

BMC cardiovascular disorders·2025

相关实验视频

Updated: May 1, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 20, 2013

18.0K

在患有天性先天性心脏病的成年人中增加了心房和大脑 natriuretic :更好地了解缺氧和 natriuretic 分泌之间的关系.

William E Hopkins1, Zengyi Chen, Naomi K Fukagawa

  • 1Department of Medicine, University of Vermont College of Medicine, Cardiology Unit, McClure 1, 111 Colchester Ave, Burlington, VT 05401, USA. william.hopkins@vtmednet.org

Circulation
|June 3, 2004
PubMed
概括

缺氧直接刺激人心细胞中心房 natriuretic (ANP) 和大脑 natriuretic (BNP) 的分泌. 这一发现对于解释心脏和肺部疾病患者的尿素水平至关重要.

更多相关视频

Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

11.7K
Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

5.1K

相关实验视频

Last Updated: May 1, 2026

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice
08:02

Isolation of Pulmonary Artery Smooth Muscle Cells from Neonatal Mice

Published on: October 20, 2013

18.0K
Isolation of Atrial Myocytes from Adult Mice
08:34

Isolation of Atrial Myocytes from Adult Mice

Published on: July 25, 2019

11.7K
Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

5.1K

科学领域:

  • 心血管生理学心血管生理学
  • 内分泌学 在内分泌学.
  • 细胞生物学 细胞生物学

背景情况:

  • 大脑天然尿素 (BNP) 对心脏病评估至关重要.
  • 缺氧对尿酸分泌的影响尚不清楚.
  • 催产素可能会影响心房 natriuretic (ANP) 的分泌.

研究的目的:

  • 为了研究缺氧对尿素分泌的影响.
  • 检查蓝色天生的心脏病患者的ANP和BNP水平.
  • 探索心脏肌细胞在缺氧诱导的尿素释放中的作用.

主要方法:

  • 研究了10名蓝色先天性心脏缺陷患者和10名对照人群.
  • 测量了N端的proANP和proBNP水平.
  • 隔离心脏肌细胞模拟缺氧和测试了催产素效应.

主要成果:

  • 阳光患者的N-终端proANP和proBNP水平显著更高.
  • 缺氧心房肌细胞显示出更少的分泌颗粒和减少的ANP/BNP.
  • 孤立的肌细胞用催产素脱粒,但催产素水平在不同组之间没有差异.

结论:

  • 在患有天性先天性心脏病的成年人中,ANP和BNP升高.
  • 缺氧直接刺激人心肌细胞中的ANP和BNP分泌.
  • 这些发现影响了BNP在心脏和肺部疾病评估中的解释.