内皮功能:动脉样硬化的一个关键决定因素?
Ulf Landmesser1, Burkhard Hornig, Helmut Drexler
1Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str.1, 30625 Hannover, Germany.
Circulation
|June 3, 2004
概括
内皮功能障碍与高胆固醇和糖尿病等疾病有关,会损害血管功能. 评估这种功能障碍可能有助于识别患有心血管疾病高风险的患者.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 生物化学 生物化学
背景情况:
- 动脉样硬化风险因素如高胆固醇血症,高血压,糖尿病和吸烟与内皮功能障碍有关.
- 内皮功能通常通过内皮依赖性血管运动进行评估,假设受损的血管扩张反映了更广泛的内皮功能障碍.
- 内皮衍生的氧化 (NO) 在血管扩张,抗炎症和抗血栓形成中起着关键作用,抑制白细胞和血小板粘附和PAI-1表达.
研究的目的:
- 为了探索受损内皮依赖血管运动的预后影响.
- 调查反应性氧物种和炎症,包括C反应性蛋白在内皮功能障碍中的作用.
- 为了确定是否评估内皮功能可以在临床上识别高风险患者.
主要方法:
- 审查关于内皮功能障碍机制和评估的现有文献.
- 对将内皮功能障碍与心血管风险因素和预后联系起来的研究进行分析.
- 检查对反应性氧物种和内皮功能障碍中的炎症途径的新兴研究.
主要成果:
- 缺陷的内皮依赖性血管运动显示出显著和独立的预后影响.
- 增加反应性氧物种的血管生产是一个常见的机制,是内皮功能障碍的基础.
- 炎症和C-反应蛋白可能直接导致内皮功能障碍.
结论:
- 对内皮功能的评估具有临床风险分层的潜力.
- 了解像反应性氧物种调节这样的机制,可能会产生新的治疗策略.
- 向内皮功能障碍可以改善心血管疾病患者的预后.
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