血大脑 natriuretic检测临床前心室缩或放缩功能障碍:一个基于社区的研究
Margaret M Redfield1, Richard J Rodeheffer, Steven J Jacobsen
1Guggenheim 9, Mayo Clinic, 200 First St, Southwest, Rochester, MN 55905, USA. redfield.margaret@mayo.edu
Circulation
|June 9, 2004
概括
血大脑尿性 (BNP) 不是查临床前心室功能障碍 (PCVD) 的可靠生物标志物. 这项研究发现,BNP在检测一般人群中心脏功能障碍的早期迹象方面是不理想的.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 预防医学 预防医学
背景情况:
- 临床前的系统性或扩张性功能障碍会增加发病率和死亡率.
- 血脑内尿性 (BNP) 被研究为临床前心室功能障碍 (PCVD) 的潜在生物标志物.
- 该研究认为,BNP的歧视性价值可能因年龄和性别而异.
研究的目的:
- 评估血BNP作为临床前腹腔功能障碍 (PCVD) 的生物标志物.
- 为了确定PNP的有效性是否随年龄和性别在识别PCVD时有所不同.
主要方法:
- 测量了2042名45岁以上的奥尔姆斯特德县居民的血BNP,心室功能 (心缩和心腹功能) 和临床参数.
- 分析了接收器运行特征曲线,以评估BNP对心和腹功能障碍的辨别能力.
- 在不同年龄组和性别中比较表现.
主要成果:
- 在严重的临床前缩功能障碍 (AUC 0.82-0.92) 和中度至重度的透缩功能障碍 (AUC 0.74-0.79) 中,BNP 的区分能力更高.
- 对BNP的歧视性值随年龄和性别而有显著差异.
- 用BNP进行查会导致大量不必要的心声回声图 (10%-40%) 并错过大量受影响个体 (10%-60%).
结论:
- 血BNP是一般人群中临床前腹腔功能障碍 (PCVD) 的次优查测试.
- 根据年龄和性别的最佳歧视值的变化进一步限制了其作为通用查工具的实用性.
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