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Updated: Jul 9, 2026

The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes
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阿里斯托洛合成酶:通过局部导向突变发生的活性部位残留物的机械分析

Brunella Felicetti1, David E Cane

  • 1Department of Chemistry, Box H, Brown University, Providence, Rhode Island 02912-9108, USA.

Journal of the American Chemical Society
|June 10, 2004
PubMed
概括

西 (Penicillium roqueforti) 的阿里斯托洛基因合成酶突变改变了产品比率,增加了中间的生殖细胞A. Tyr-92突变证实了这一点.

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Allosteric Proteins-ATCase01:19

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...