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Updated: Jun 22, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

在p53的转录激活中,PRMT1,p300和CARM1的有序合作功能

Woojin An1, Jaehoon Kim, Robert G Roeder

  • 1Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA.

Cell
|June 10, 2004
PubMed
概括

这项研究揭示了蛋白质氨酸甲基转移酶PRMT1和CARM1,与p300一起,对于通过直接相互作用和基因素修饰来激活p53依赖基因至关重要. 这些协同激活剂独立而合作地起作用,通过特定的基因素标记影响基因表达.

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