依赖于髓的结节重塑控制平面细胞间隙和轴延长
Claire Bertet1, Lawrence Sulak, Thomas Lecuit
1Laboratoire de Génétique et de Physiologie du Développement, Institut de Biologie du Développement de Marseille, CNRS-INSERM-Université de la Méditerranée, Campus de Luminy, case 907, 13288 Marseille cedex 9, France.
Nature
|June 11, 2004
概括
细胞间隙通过重组细胞结合点驱动上皮质形态发生. 肌酸二的活性对这个过程至关重要,为组织发育提供了一个一般模型.
科学领域:
- 发育生物学是发展生物学.
- 细胞生物学 细胞生物学
- 生物物理学的生物物理.
背景情况:
- 组织的成型 (形态发生) 取决于细胞分裂,形状和邻居通过介质变化而发生的变化.
- 由附着结节维持的上皮质完整性,为合提出了独特的挑战.
研究的目的:
- 阐明有序细胞间隔驱动偏振表皮形态发生的机制.
- 了解细胞连接和力量在Drosophila胚胎中的生殖带延长中的作用.
主要方法:
- 在Drosophila胚胎的细胞间隔过程中研究了结节重塑.
- 分析了局部力量和myosin II在平面结重塑中的作用.
主要成果:
- 细胞间接是通过粘附结的空间重组来进行的.
- 平面结重塑是由局部力量驱动的,而不是外部组织力量.
- 在拆卸接口中丰富的myosin II对于平面重塑和间接是必不可少的.
结论:
- 提出了一个用于两极化上皮质形态发生的新型细胞机制.
- 局部力量和依赖于myosin II的连接重塑驱动细胞间隙.
- 这种机制为表皮器官发育提供了一个一般模型.
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