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在喘Th2炎症和IL-13通路激活中的酸性哺乳动物奇丁酶

Zhou Zhu1, Tao Zheng, Robert J Homer

  • 1Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, Department of Internal Medicine, 300 Cedar Street, TAC S-441, New Haven, CT 06520-8057, USA.

Science (New York, N.Y.)
|June 12, 2004
PubMed
概括

酸性哺乳动物基因酶 (AMCase) 在喘中升高,由T助手-2 (Th2) 和互白素-13 (IL-13) 途径驱动. 中和AMCase在喘模型中降低了呼吸道炎症和高反应性.

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...