核酸胆两性素的超分子组合
Louis Moreau1, Philippe Barthélémy, Mohamed El Maataoui
1Faculté des sciences d'Avignon 33, rue Louis Pasteur, F-84000 Avignon, France.
Journal of the American Chemical Society
|June 17, 2004
概括
新的尿素胆两性体会自我组装成各种超分子结构,如纤维,囊泡和水凝. 这些结构是热可逆的,可以封装像DNA这样的治疗剂.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 生物材料是一种生物材料.
背景情况:
- 尿素胆氨基双性子是新型分子,在药物输送和生物材料中具有潜在的应用.
- 了解它们的自我组装行为对于设计功能性的超分子系统至关重要.
研究的目的:
- 为了合成和表征一种新的尿素胆两性动物家族.
- 研究这些两动物在水和有机溶液中的自我组装特性.
- 探索这些两动物在形成用于治疗剂封装的水凝和器官凝方面的潜力.
主要方法:
- 两动物制备的四步合成路径.
- 使用差分扫描热度计,小角度X射线散射,紫外线和圆形二极化谱的物理化学表征.
- 显微镜技术包括光,传输电子显微镜 (TEM) 和扫描电子显微镜 (SEM).
主要成果:
- 合成的两生物自发地组装成各种各样的超分子结构:囊泡,纤维,水凝和有机凝.
- 具有和基链的两类分子在晶体状态中形成类似DNA的螺旋纤维,并在化温度 (Tm) 以上的双层中形成.
- 观察到双层和纤维之间的热可逆过渡. 形成在6%重量/重量度以上的水凝,能够捕获DNA. 器官凝是在环素中形成的.
结论:
- 新的尿素胆两性体表现出多才多艺的自我组装行为,形成各种超分子结构.
- 这些两性物体显示出作为功能性水凝和器官凝的构建块的潜力,在药物输送系统中具有应用.
- 自组装的热可逆性为材料设计提供可调节的特性.
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