刺响应网络:传感器,交换机和路由器
Lawrence Lum1, Philip A Beachy
1Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
概括
刺 (Hh) 信号通路控制细胞生长和发育. 新的发现揭示了一种kinesin运动蛋白对于传输Hh信号从细胞膜到细胞质至关重要,影响通路激活.
科学领域:
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
- 发展生物学 发展生物学
背景情况:
- 刺 (Hh) 信号通路在胚胎发育,组织平衡和癌症中起着至关重要的作用.
- Hh信号的失调与瘤的开始和进展有关.
- 了解Hh信号传导对于治疗干预至关重要.
研究的目的:
- 阐明Hh信号转导的新机制.
- 为了确定参与Hh通路的新组件.
- 描述滑化在通路激活中的作用.
主要方法:
- 研究了Smoothened和细胞内信号组件之间的相互作用.
- 利用生物化学分析来识别参与Hh信号传递的蛋白质复合体.
- 在细胞模型中检查了已识别的途径组件的功能.
主要成果:
- 确定了一种非典型的激素作为Hh信号传输的关键媒介.
- 已经证明,Smoothened使用这种激素来促进信号传播.
- 描述了素与含有转录因子Ci的复合物的相互作用.
结论:
- 非典型的素是Hh信号通路的一个新组成部分.
- 信号传输涉及从膜到细胞质的基因素介导的传输.
- 这种机制为Hh通路调节和潜在的治疗点提供了新的见解.
相关概念视频
Signal Transduction: Overview
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Typically, signal transduction involves three...
Typically, signal transduction involves three...
Network Function of a Circuit
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Overcurrent Relays
Overcurrent relays, crucial for circuit protection, are connected to the secondary current of a current transformer. There are two primary types of overcurrent relays: instantaneous and time-delay.
Instantaneous overcurrent relays activate immediately when the input current exceeds a predetermined value, known as the pickup current, instantly energizing the circuit breaker trip coil. This rapid response is vital for addressing severe faults quickly.
Time-delay overcurrent relays, on the other...
Instantaneous overcurrent relays activate immediately when the input current exceeds a predetermined value, known as the pickup current, instantly energizing the circuit breaker trip coil. This rapid response is vital for addressing severe faults quickly.
Time-delay overcurrent relays, on the other...
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A comprehensive protection scheme for radial distribution...
A comprehensive protection scheme for radial distribution...
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Under normal conditions, low load currents keep the measured...
Under normal conditions, low load currents keep the measured...
Pilot and Numeric Relaying
Pilot relaying is a type of differential protection used in power systems. It compares electrical quantities at the terminals of equipment via a communication channel instead of direct relay interconnection. This method is essential for transmission lines where the terminals are far apart, typically up to 80 km for lines with 69 to 115 kV ratings. Four types of communication channels are used for pilot relaying:


