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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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通过LARGE进行分子识别对于功能性消极糖的表达至关重要

Motoi Kanagawa1, Fumiaki Saito, Stefan Kunz

  • 1Howard Hughes Medical Institute, Department of Physiology and Biophysics, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242, USA.

Cell
|June 24, 2004
PubMed
概括

通过LARGE对dystroglycan的分子识别对于功能性糖化非常重要,可以预防肌肉和中枢神经系统疾病. 这种酶基质相互作用启动了成熟的途径,对于肌肉健康至关重要的功能性消毒甘油.

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Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and 'exit' via the...