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Murine Kidney Transplant Technique
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在成功进行移植的儿童和青少年中,动脉结构和功能异常
Mark M Mitsnefes1, Thomas R Kimball, Sandra A Witt
1Division of Nephrology and Hypertension, Cincinnati Children's Hospital, MLC 7022, 3333 Burnet Ave, Cincinnati, Ohio 45229-3039, USA. mark.mitsnefes@cchmc.org
Circulation
|June 24, 2004
概括
成功移植脏的儿童表现出动脉疾病的迹象,包括内心介质厚度增加和延展能力降低. 这些血管变化与高血压有关,可能会增加他们早发心血管疾病的风险.
科学领域:
- 儿科脏病学 儿科脏病学
- 心血管研究研究心血管研究
- 血管生物学 血管生物学
背景情况:
- 慢性功能衰竭的成年人表现出动脉异常 (动脉样硬化标志物).
- 有限的数据存在于儿童脏移植接受者的这些血管变化.
研究的目的:
- 评估关动脉结构和功能,在移植后的儿童.
- 在这个人群中识别与血管异常相关的因素.
主要方法:
- 在31名儿童移植接受者和33名对照者中,动脉的超声波和回声心脏学.
- 测量亲密介质厚度 (IMT),延展性和刚度参数 (β).
- 门诊血压监测和与临床/生化数据的相关性.
主要成果:
- 与对照组相比,移植受体的IMT和β值较高,抗张能力较低.
- 增加的IMT与较高的缩血压和多次移植相关.
- 异常延展性和β与较高的白天静脉血压负荷和尸体脏相关.
- 抗高血压药物的数量独立预测了异常延展性和β.
结论:
- 成功进行移植的儿童表现出动脉动脉病变.
- 高血压是一个重要的相关因素.
- 这些儿童可能面临加速动脉样硬化和早发性心血管疾病的风险增加.
相关概念视频
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