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未来冠状动脉事件的死亡率与炎症敏感的血蛋白有关:基于人口的前性队列研究
Gunnar Engström1, Bo Hedblad, Lars Stavenow
1Department of Community Medicine, Malmö University Hospital, S-20502 Malmö, Sweden. gunnar.engstrom@smi.mas.lu.se
Circulation
|June 24, 2004
概括
健康男性的低度炎症预测未来冠状动脉事件的死亡率更高. 升高的炎症敏感血蛋白表明冠心病死亡风险增加,而不仅仅是非致命事件.
科学领域:
- 心脏病学 心脏病学
- 炎症研究 炎症研究
- 预防医学 预防医学
背景情况:
- 经历第一次急性冠状动脉事件的男性中,大约40%在第一天死亡,通常是在获得医疗护理之前.
- 健康个体中低度炎症对未来冠状动脉事件的死亡率的预测价值在很大程度上是未知的.
研究的目的:
- 为了调查是否预先存在的低级炎症,由炎症敏感血蛋白 (ISP) 表示,预测了看似健康的男性冠状动脉事件的死亡率.
主要方法:
- 在6075名健康男性中测量了5种炎症敏感血蛋白 (ISP).
- 随访参与者的平均时间为19年,确定了680人经历了第一次冠心病 (非致命的心肌梗塞或冠心病死亡).
- 分析了基线ISP水平与事件死亡率 (包括过早死亡) 之间的关联.
主要成果:
- 升高的ISP显着与非致命的心肌梗塞和冠心病死亡相关.
- 冠心病死亡的相对风险高于非致命的心肌梗塞.
- 在患有冠状动脉事件的男性中,在基线时较多的ISP升高与致命事件的比例增加相关,包括28天内死亡.
结论:
- 几年前有轻度炎症证据的男性在未来的冠状动脉事件中面临更高的死亡率.
- 这表明,冠状动脉疾病导致的死亡比例较高,这些人中非致命事件较少.
- 在对心血管疾病的初级预防进行风险评估时,应考虑炎症标志物.
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