结合性马类雌激素和绝经后妇女的全球认知功能:妇女健康倡议记忆研究
Mark A Espeland1, Stephen R Rapp, Sally A Shumaker
1Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. mespelan@wfubmc.edu
JAMA
|June 24, 2004
概括
结合性马类雌激素 (CEE) 治疗对老年妇女的认知功能产生负面影响. 这种不良影响在具有较低基线认知功能的患者中更为明显.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 之前的妇女健康倡议记忆研究 (WHIMS) 研究表明,雌激素加孕激素治疗对65岁以上的女性没有认知保护.
- 雌激素单独治疗对这一人口群体认知的影响仍然未确立.
研究的目的:
- 评估合马雌激素 (CEE) 对绝经后妇女全球认知功能的影响.
- 为了比较CEE的认知效应与CEE加美德酸 (CEE加MPA) 的认知效应.
主要方法:
- 一个随机的,双盲的,安慰剂对照试验,涉及2808名65-79岁的女性,先前进行过子宫切除.
- 参与者每天接受CEE (0.625毫克) 或安慰剂.
- 全球认知功能每年使用修改的迷你精神状态检查 (3MSE) 进行评估.
主要成果:
- 与安慰剂相比,CEE治疗与3MSE得分的统计学上显著下降有关 (P=.04).
- 组合激素治疗 (CEE和CEE加MPA) 也显示出显著的认知能力下降 (P=.006).
- 在基线认知功能较低的女性中,不良认知影响更为明显.
结论:
- 激素治疗,包括CEE,对65岁及以上妇女的认知功能产生不利影响.
- 对认知的负面影响在初始认知功能较低的女性中加剧.
相关概念视频
02:07Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
01:28Infertility in Females
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...
Endometriosis, a condition characterized by abnormal growth of endometrial...