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Updated: Aug 11, 2026

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System
14:09

Genetic Studies of Human DNA Repair Proteins Using Yeast as a Model System

Published on: March 18, 2010

一个人类DNA修复基因的表达克隆,该基因涉及色素菌C组

R Legerski1, C Peterson

  • 1Department of Molecular Genetics, University of Texas, M. D. Anderson Cancer Center, Houston 77030.

Nature
|September 3, 1992
PubMed
概括

研究人员确定了一种DNA修复基因,XPCC,对于纠正Xeroderma pigmentosum补充组C (XP-C) 细胞中的DNA损伤至关重要. 这一发现促进了对DNA修复机制和Xeroderma pigmentosum (XP) 疾病的理解.

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Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells12:04

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Published on: March 10, 2023

相关概念视频

Mismatch Repair01:36

Mismatch Repair

Overview
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
Base Excision Repair01:54

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...