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Updated: Aug 11, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
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Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions

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矩阵金属蛋白酶抑制剂的新开端:识别高亲和度结合群

David T Puerta1, Jana A Lewis, Seth M Cohen

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.

Journal of the American Chemical Society
|July 9, 2004
PubMed
概括

新的结合组 (ZBGs) 显示出对矩阵金属蛋白酶 (MMPs) 的强烈抑制. 这些非酸盐抑制剂在药物应用中提高了针对MMP的性能.

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相关概念视频

Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.