含有异黄的大豆蛋白对绝经后妇女的认知功能,骨矿物质密度和血脂的作用:一项随机对照试验
Sanne Kreijkamp-Kaspers1, Linda Kok, Diederick E Grobbee
1The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands.
JAMA
|July 9, 2004
概括
在60岁及以上的健康绝经后妇女中,大豆异黄补充剂没有改善认知功能,骨矿物质密度或血脂质. 这项研究发现,每天摄入大豆蛋白对这些衰老标志物没有显著的益处.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 妇女健康 妇女健康
背景情况:
- 绝经后雌激素治疗提供了好处,但也带来了风险.
- 在大豆中发现的异黄是具有类似雌激素的特性的植物化合物,可能会在较少的风险下提供益处.
- 调查大豆异黄作为更安全的替代品对于更年期后的健康是有必要的.
研究的目的:
- 为了确定含有异黄的大豆蛋白是否能提高绝经后妇女的认知功能.
- 评估大豆异黄对绝经后妇女骨矿物质密度的影响.
- 评估大豆异黄对绝经后妇女血脂质谱的影响.
主要方法:
- 一个为期12个月的双盲,随机,安慰剂控制试验,涉及202名健康的60-75岁的绝经后妇女.
- 参与者每天接受大豆蛋白与异黄 (99毫克) 或牛奶蛋白安慰剂.
- 测量了认知功能,骨矿物质密度 (部和腰椎),以及血脂质.
主要成果:
- 175名女性完成了这项研究;坚持是好的.
- 在12个月后,大豆和安慰剂组在认知功能方面没有发现显著差异.
- 与安慰剂相比,大豆组的骨矿物质密度和血脂水平也没有显著改善.
结论:
- 用异黄补充大豆蛋白并没有改善60岁以上健康的绝经后妇女的认知功能.
- 这种干预没有导致骨矿物质密度或血脂质的显著变化.
- 这些发现不支持使用大豆异黄来改善这些特定的健康标志物.
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