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An In Vivo Mouse Model to Measure Naïve CD4 T Cell Activation, Proliferation and Th1 Differentiation Induced by Bone Marrow-derived Dendritic Cells
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在体外将细胞生物学转化为体内免疫

Marianne Boes1, Hidde L Ploegh

  • 1Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA. Marianne_boes@hms.harvard.edu

Nature
|July 9, 2004
PubMed
概括

天生的免疫防御系统与病原体作斗争,但如果失败,T细胞和B细胞等淋巴细胞提供适应性免疫力. 了解体内T细胞激活是治疗传染病和自身免疫性疾病的关键.

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...