生理学:肠道激素PYY3-36是否会降低动物的食物摄入量?
M Tschöp1, T R Castañeda, H G Joost
1Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, Ohio 45237, USA. tschoemh@ucmail.uc.edu
Nature
|July 13, 2004
概括
对肠道激素PYY3-36,一种潜在的肥胖治疗方法的复制研究失败了. 这些发现质疑PYY3-36对抗肥胖治疗的可行性.
科学领域:
- 内分泌学 在内分泌学.
- 肥胖问题研究研究
- 胃肠道激素 胃肠道激素
背景情况:
- 据报道,肠道激素PYY3-36可以减少动物的食物摄入量和体重.
- 这一发现表明PYY3-36是潜在的新型治疗肥胖的新疗法.
相关概念视频
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Regulation of Food Intake
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...


