通过电子束计算断层扫描测量的大动脉结石化的评估和临床影响
David Messika-Zeitoun1, Marie-Christine Aubry, Delphine Detaint
1Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minn 55905, USA.
Circulation
|July 14, 2004
概括
电子束计算机断层扫描准确地测量了大动脉结石化 (AVC),有助于诊断严重的大动脉狭窄 (AS). 这种方法为AS患者提供了独立的预后信息.
科学领域:
- 心血管成像 - 心血管成像
- 放射学 放射学是一门学科.
- 膜心脏疾病 膜心脏疾病
背景情况:
- 电子束计算断层扫描 (EBCT) 确立为冠状动脉化,但不是大动脉膜化 (AVC).
- 对于AVC的EBCT的准确性,诊断和预后价值及其与大动脉狭窄症 (AS) 严重程度的关联以前是未知的.
研究的目的:
- 评估EBCT用于测量AVC的准确性和可重复性.
- 评估通过EBCT测量的AVC与AS严重程度之间的关联.
- 确定AS患者AVC的诊断和预后价值.
主要方法:
- 对30个探索的大动脉膜的ex vivo分析,以将EBCT AVC得分与病理学量相关联.
- 在体内测量AVC通过EBCT和AS严重程度通过心声谱大动脉面积 (AVA) 在100名患者.
- 纵向随访以评估无事件存活率.
主要成果:
- EBCT AVC 评分与病理学量 (r=0.96) 有很强的相关性,使得准确的估计.
- 在AVC和AVA之间发现了强烈的关联 (r=0.79),表明了互补的信息.
- 一个AVC评分≥1100AU表明93%的敏感性和82%的特异性严重的AS.
- 升高的AVC得分独立地预测不良事件,即使在调整心声学发现后.
结论:
- EBCT提供了一种准确和可重复的方法来测量AVC.
- 通过EBCT测量AVC对于诊断严重的AS是有价值的,并提供独立的预后信息.
- 将AVC评估与AVA结合起来,可以为AS患者提供全面的评估.
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