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A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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使用Et2Zn/链接-BINOL复合体的基的直接催化不对称曼尼赫式反应:合成抗或合成β-氨基醇

Shigeki Matsunaga1, Takamasa Yoshida, Hiroyuki Morimoto

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|July 15, 2004
PubMed
概括

这项研究详细介绍了一种直接的催化不对称的曼尼赫式反应,使用一种与结合的BINOL复合物. 通过调整 imine 保护组,反应有效地产生具有高立体选择性的反或 syn-beta 氨基醇.

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