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Updated: Apr 30, 2026

Chromatin Immunoprecipitation ChIP using Drosophila tissue
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Chromatin Immunoprecipitation ChIP using Drosophila tissue

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染色体调节了Drosophila毛囊细胞中的起源活性

Bhagwan D Aggarwal1, Brian R Calvi

  • 1Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA.

Nature
|July 16, 2004
PubMed
概括

染色素乙化对于甲基动物的DNA复制原始特异性至关重要. 希斯乙化调节起源识别复合体 (ORC) 结合和起源活动在发育过程中.

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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