系统性红斑狼:女性内皮功能障碍的一个独立风险因素
Masoud El-Magadmi1, Helena Bodill, Yasmeen Ahmad
1University of Manchester arc Epidemiology Unit, Manchester Royal Infirmary, Central Manchester and Manchester Children's University Hospitals NHS Trust, Manchester, UK.
Circulation
|July 21, 2004
概括
系统性红斑狼 (SLE) 患者表现出内皮功能障碍,这是冠心病 (CHD) 发展的关键因素,即使考虑到传统的风险因素. 这种功能障碍与早期动脉样硬化标志物有关.
科学领域:
- 心脏病学 心脏病学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 系统性红斑狼 (SLE) 与冠状动脉病 (CHD) 风险增加有关,超过已确定的因素.
- 内皮功能障碍是动脉样硬化的早期指标.
- 在SLE患者中,内皮功能障碍与传统风险因素的存在和关联需要进行调查.
研究的目的:
- 调查SLE患者内皮功能障碍的发生情况.
- 为了确定SLE中的内皮功能障碍是否与经典的弗雷明翰风险因素有关.
主要方法:
- 流媒扩张 (FMD) 评估了62名患有SLE的女性和38名健康对照者的内皮功能.
- 在SLE患者中评估了心动脉内心介质厚度 (IMT) 和斑块存在.
- 多重回归分析确定了与受损的口病相关的因素.
主要成果:
- 与健康对照组相比,SLE患者表现出明显减弱的口炎 (P<0.01).
- 系统性血压和SLE本身独立地与受损的口炎相关.
- 在SLE患者中,IMT与口病有负相关性 (r=-0.37,P<0.01),表明与早期动脉样硬化有联系.
结论:
- 在SLE患者中,内皮功能障碍很普遍,独立于传统的心脏病风险因素.
- 在SLE中内皮功能障碍与IMT相关,IMT是亚临床动脉样硬化的标志物.
- 对与SLE相关的内皮功能障碍机制的进一步研究可能会揭示新的心血管疾病预防策略.
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