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通过Pyrrole-imidazole S-CBI结合物进行EnantioselectiveDNA基化

Toshikazu Bando1, Akihiko Narita, Ken Asada

  • 1Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8501, Japan.

Journal of the American Chemical Society
|July 22, 2004
PubMed
概括

合成了N-methylpyrrole (Py) -N-methylimidazole (Im) 聚胺与环烯indole (CBI) 进行了合成. 12S反体选择性化DNA,显示出比CPI合物更高的效率,而12R则较弱.

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Maxam-Gilbert Sequencing01:05

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In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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