发育可塑性和人类健康
Patrick Bateson1, David Barker, Timothy Clutton-Brock
1Sub-Department of Animal Behaviour, University of Cambridge, High Street, Madingley, Cambridge CB3 8AA, UK. ppgb@cam.ac.uk
Nature
|July 23, 2004
概括
生物通过发育性可塑性适应环境,受早期生活和父母暴露的影响. 快速的环境变化可能会带来健康风险,影响公共卫生战略.
科学领域:
- 发育生物学是发展生物学.
- 进化生物学是进化的生物学.
- 人类健康 人类健康 人类健康
背景情况:
- 生物体表现出表型可塑性,适应尺寸和新陈代谢等特征的环境条件.
- 早期或父母的暴露可以诱导发育适应,为预测的环境准备后代.
- 对一个环境的发展适应可以在个体在以后的生活中遇到新条件时造成脆弱性.
研究的目的:
- 探索发育性可塑性的生物学基础,以应对环境因素.
- 了解早期营养和环境因素如何影响人类发育和疾病易感性.
- 检查稀缺期后快速环境改善对健康的矛盾后果.
主要方法:
- 对植物和动物表型可塑性的生物证据的审查.
- 对人类发育变化的分析,以应对改善的孕产妇营养.
- 考虑环境暴露的代际影响.
主要成果:
- 发育可塑性允许生物体将特征与环境条件相匹配,优化生存或繁殖.
- 后代的特征,包括体型和新陈代谢,受到母亲的营养状况的影响.
- 生活条件的快速改善可以悖论地伤害那些祖先经历贫困的人.
结论:
- 了解人类发育可塑性对于预测健康结果至关重要.
- 早期环境暴露和营养显著影响长期健康和疾病风险.
- 公共卫生倡议必须考虑发展可塑性和环境变化的长期影响.
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