在解剖研究中,积极和被动吸烟以及肺癌风险的病理指标在解剖研究中
D Trichopoulos1, F Mollo, L Tomatis
1Department of Epidemiology, Harvard School of Public Health, Boston, Mass 02115.
JAMA
|October 7, 1992
概括
这项在希腊的尸体解剖研究发现,通过表皮损伤表明的被动吸烟与肺癌风险有关. 结果显示,与吸烟者结婚的女性的病变更高,支持被动烟的证据.
科学领域:
- 肺病理学和环境致癌.
- 肺癌和吸烟相关疾病的流行病学.
背景情况:
- 流行病学研究表明,强迫吸烟 (被动吸烟) 和肺癌之间存在联系.
- 在以前的研究中对偏见的担忧仍然存在,需要使用替代研究方法.
- 基于尸检的研究很少见,没有一个专门研究过被动吸烟在肺癌发生中的作用.
研究的目的:
- 为了对被动吸烟在肺癌发生中的作用进行基于尸检的调查.
- 检查肺组织上皮质变化作为肺癌风险的潜在指标.
- 探索吸烟习惯,被动烟雾暴露和肺样本中的病理发现之间的联系.
主要方法:
- 从希腊雅典的400次尸检 (年龄≥35) 中收集了肺样本,不包括呼吸道或癌症死亡.
- 支气管上皮的组织病理学检查,以发现像基底细胞增生和转化 (EPPL) 这样的病变.
- 对206名受试者的亲属进行的采访提供了有关死者和配偶的吸烟习惯的数据;采访者对病理结果是盲目的.
主要成果:
- 与非吸烟者相比,目前吸烟者的上皮,可能是癌前的病变 (EPPL) 显著增加.
- 在与吸烟者结婚的非吸烟妇女中,EPPL值明显高于与非吸烟者结婚的妇女.
- 里德指数显示,吸烟者和城市居民的价值趋向于更高,但差异在统计学上并不显著.
结论:
- 这些发现支持被动吸烟与肺癌风险之间的关联.
- 这项基于尸检的研究提供了新的证据,补充了现有的流行病学数据.
- 需要进一步的研究,以充分阐明与被动烟雾暴露与肺癌发生有关的机制.
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