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Updated: Jun 25, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

在p53-hDM2相互作用的螺旋β-抑制剂

Joshua A Kritzer1, James D Lear, Michael E Hodsdon

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.

Journal of the American Chemical Society
|August 5, 2004
PubMed
概括

研究人员设计了新的β3,模仿p53转激活域 (p53AD) 结构. 这些因高亲和力结合hDM2,通过破坏p53.hDM2相互作用,为癌症治疗提供了一种新的策略.

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