来自功能化的基因的oxasilacyclopentenes的形成和实用性
1Department of Chemistry, University of California, Irvine, California 92697-2025, USA.
Journal of the American Chemical Society
|August 5, 2004
概括
合成有用的oxasilacyclopentenes是使用银催化剂从基中创建的. 这些化合物作为掩盖的合醇,在随后的转化中表现出广泛的功能组耐受性和多功能反应性.
科学领域:
- 有机化学 有机化学
- 有机化学 有机化学
背景情况:
- 醇是有价值的合成中间体.
- 它们的合成和功能化的高效方法在有机化学中至关重要.
研究的目的:
- 开发一种新型的合成路径,以获得oxasilacyclopentenes.
- 为了探索oxasilacyclopentenes作为掩盖的醇的实用性. 为了探索oxasilacyclopentenes作为掩盖的醇的实用性.
- 通过进一步的转换来证明这些化合物的合成多功能性.
主要方法:
- 终端和内部基因的白银催化环化.
- 碳化合物的在位插入到cyclopropenes.
- 氧化的二氧化选择性化.
- 迪尔斯-阿尔德反应利用了维尼尔西兰的功能.
主要成果:
- 氧环烯在高产量和区域选择性中进行了合成.
- 该方法证明了对各种功能组的耐受性.
- 通过碳基插入实现了氧环烯的区域选择性形成.
- 随后的反应,包括化和Diels-Alder反应,证实了乙烯基部分的合成效用和反应性.
结论:
- 奥克萨西拉cyclopentenes是合成有用的掩饰基醇.
- 开发的方法为这些化合物提供了高效的访问,具有广泛的功能组耐受性.
- 在oxasilacyclopentenes中的vinylsilane功能使多样化和 diastereoselective转换成为可能.
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