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用于消毒受污染的医疗器械的新方法
Guillaume Fichet1, Emmanuel Comoy, Christelle Duval
1CEA/DSV/DRM/GIDTIP, Route du Panorama, 92265 Fontenay-aux-Roses, France.
新的方法有效地使医疗器械上的子失活,包括蒸发过氧化 (VHP). 这些发现为仪器和表面提供了更安全的脱污,防止像克鲁茨菲尔特-雅各布病变体这样的普里昂疾病.
科学领域:
- 传染病控制和控制传染病
- 生物化学 生物化学
- 材料科学 材料科学 材料科学
背景情况:
- 子抵御标准的消毒,通过医疗器械构成感染风险.
- 变体克鲁茨菲尔特-雅各布病 (vCJD) 病原体的广泛分布需要改进的离子失活方法.
- 医疗保健设施面临的挑战是对仪器和表面进行脱污染,以防止性疾病.
研究的目的:
- 评价用于非活化的创新物理和化学去污方法.
- 开发和使用体外和体外模型来测试净化疗效.
- 确定可行的程序,以确保医疗和手术仪器的安全.
主要方法:
- 通过使用受污染的不钢电线,调整了一个活体子适应的Scrapie菌株263K模型.
- 开发了一种体外表面污染协议,用于生物化学检测抗蛋白酶的蛋白 (PrP(res)).
- 研究了各种物理 (自封) 和化学 (消毒剂,VHP) 消毒方法的有效性.
主要成果:
- 标准方法 (NaOH,NaOCl,在水中自封) 实现了>5.6 log10的感染性降低.
- 在没有浸泡的情况下进行自闭包,可使传染性降低4-4.5 log.
- 较温和的治疗方法,包括性消毒剂,性清洁剂和用VHP的酶性清洁剂是有效的. 仅VHP就实现了4.5日志的减少.
结论:
- 蒸发过氧化 (VHP) 提供了一种与电子元件兼容的有效的离子失活方法.
- 对于无法承受当前高级别无效化方法的医疗仪器和表面,提出了新的除污处理程序.
- 这些进展旨在提高安全性,并防止卫生保健机构中性疾病的转移.
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