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血管新生和血管新生在早期衰老的klotho小鼠中受损
Toshifumi Shimada1, Yoshiaki Takeshita, Toyoaki Murohara
1Cardiovascular Research Institute, Kurume University, Kurume, Japan.
Circulation
|August 11, 2004
概括
在克洛托突变小鼠中,衰老会损害血管形成,包括血管生成和血管生成. 类固醇药物治疗可能为与年龄相关的新血管化衰退提供一种新的治疗方法.
科学领域:
- 血管生物学 血管生物学
- 衰老研究研究 衰老研究
- 再生医学是一种再生医学.
背景情况:
- 衰老对血管生成和血管生成的影响尚不清楚.
- 克洛托 (kl) 突变小鼠作为典型衰老的模型.
研究的目的:
- 在克洛托突变小鼠中研究缺血诱导的血管生成和血管生成的变化.
主要方法:
- 在克洛托突变小鼠中的后肢缺血模型.
- 激光多普勒血流分析 (LDBF) 和毛细血管密度评估.
- 大动脉环培养试验和内皮前体细胞 (EPC) 结合的评估.
主要成果:
- 克洛托突变小鼠在缺血后表现出血流恢复和毛细血管密度降低.
- 在kl/kl小鼠中观察到血管新生障碍和氧化释放.
- 在kl/kl小鼠中,EPCs在新血管中被减少了,这与较少的c-Kit+CD31+细胞有关.
结论:
- 根据klotho缺乏的模型,衰老会损害血管生成和血管生成.
- 立方体治疗,特别是定,可以恢复老年小鼠的新血管化.
- 用他类药物准与年龄相关的新血管化衰退是一种潜在的治疗策略.
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