在急性冠状动脉综合征中,血 ангиопоэтин-1, ангиопоэтин-2, ангиопоэтин受体结合-2,以及血管内皮生长因子水平
Kaeng W Lee1, Gregory Y H Lip, Andrew D Blann
1Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.
Circulation
|August 11, 2004
概括
在急性冠状动脉综合征患者中,血管内皮生长因子 (VEGF) 和血管内皮生长因子 (Tie-2) 的血水平增加. 这些因素在心肌梗塞恢复期间显示出动态变化,反映出血管生成活动.
科学领域:
- 心血管生物学 心血管生物学
- 血管新生研究研究
- 生物标志物发现发现
背景情况:
- 血管蛋白 (Ang-1,Ang-2),它们的受体Tie-2和VEGF是血管生成的关键调节者.
- 这些因素都与心脏的附带发展有关.
- 之前的研究发现心肌梗塞 (MI) 的水平升高,但事件后的动态变化是未知的.
研究的目的:
- 在急性冠状动脉综合征 (ACS) 患者中调查Ang-1,Ang-2,Tie-2和VEGF的血水平.
- 为了分析这些生物标志物的连续变化,从急性到慢性阶段的MI.
- 了解它们在缺血性心脏事件的恢复期间在血管生成中的作用.
主要方法:
- 在基线和48小时内从126名ACS患者 (82次MI,44次不稳定性胸痛) 收集了血样本.
- 这些水平与40名稳定性胸痛患者和40名健康对照人进行了比较.
- 在6周和18周 (慢性阶段) 的38名心脏病发作患者中重复测量.
主要成果:
- 在心脏病发作患者中,基线Ang-2和Tie-2水平显著更高.
- 与对照人群相比,心脏病发作和不稳定性胸痛患者的VEGF水平升高.
- 序列分析揭示了动态变化:Ang-1增加较晚,Ang-2显示两相变化,Tie-2仍然升高,VEGF在MI后6周达到峰值.
结论:
- 在急性冠状动脉综合征中,血Ang-2,Tie-2和VEGF水平升高.
- 在急性阶段,Ang-1水平没有显著增加.
- 观察到的这些生物标志物的连续变化表明,在心肌梗塞恢复期间,心肌肌中的血管生成活动正在演变.
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