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Updated: Jul 20, 2026

Specific Marking of HIV-1 Positive Cells using a Rev-dependent Lentiviral Vector Expressing the Green Fluorescent Protein
09:53

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Published on: September 23, 2010

野生类型和突变HIV蛋白酶的小分子二分化抑制剂:集中图书馆方法

Michael D Shultz1, Young-Wan Ham, Song-Gil Lee

  • 1Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.

Journal of the American Chemical Society
|August 12, 2004
PubMed
概括

研究人员开发了抑制剂,阻止HIV-1蛋白酶二分化,这是病毒复制的关键步骤. 结合修改显著提高了抑制剂的功效,提供了一个有前途的补充策略,积极的网站药物向.

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Inhibitors of Virion Maturation and Assembly01:19

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As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...