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Updated: Jul 21, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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在合成和PCRDNA模板上的单核酸特异性PNA结

Simon Ficht1, Amos Mattes, Oliver Seitz

  • 1Institut für Chemie, Humboldt-Universität zu Berlin, Brook-Taylor-Strasse 2, D-12489 Berlin, Germany.

Journal of the American Chemical Society
|August 12, 2004
PubMed
概括

核酸 (PNA) 结合物使得DNA分析的高度选择性化学结合成为可能. 这种方法允许在双链DNA中快速检测单基基因突变,从而推进分子诊断.

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相关概念视频

PCR01:32

PCR

Overview
PCR - Polymerase Chain Reaction01:32

PCR - Polymerase Chain Reaction

Overview
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...