接种疫苗的病例中麻疹的传染性:家庭接触研究
Jane F Seward1, John X Zhang, Teresa J Maupin
1Centers for Disease Control and Prevention, Atlanta, Ga 30333, USA. jseward@cdc.gov
JAMA
|August 12, 2004
概括
脊髓灰质炎疫苗非常有效,预防了大约80%的水病例和几乎所有中度到重度感染. 疫苗接种过的突破性感染者比未接种疫苗的人更容易感染,尤其是那些病变较少的人.
科学领域:
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 有限的数据存在于接种疫苗的个体中 (天花) 的传染性.
- 了解疫苗接种人群中的传播动态对于公共卫生战略至关重要.
研究的目的:
- 根据病史和疫苗接种状况,确定家庭内的二次攻击率.
- 为了估计水疫苗的有效性.
主要方法:
- 在洛杉矶县 (1997-2001) 开展的一项以人口为基础的监测项目,追踪了水病例.
- 收集的数据包括人口统计,临床细节,病例和家庭接触者的疫苗接种状况.
- 使用未接种疫苗和接种疫苗的个人数据计算了二次攻击率和疫苗的有效性.
主要成果:
- 接种疫苗的病例的传染性是未接种疫苗的病例的一半.
- 疫苗预防任何水疾病的有效率为78.9%.
- 适度疾病的有效性达到92%,严重疾病的有效性达到100%.
结论:
- 脊髓灰质炎疫苗在预防中度和重度疾病方面表现出很高的有效性,即使在强烈的家庭暴露下也是如此.
- 在接种疫苗的人中,突破性水感染的传染性比未接种疫苗的人少.
- 突破病例的传染性与皮肤病变的数量相关.
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